Table 2.
Individual and Pharmacy Level Variables Available for Multivariable Analysis
| Variable | Description | Database Source |
|---|---|---|
| Individual Level | ||
| Sex | Sex of subject | Insurance registry |
| Age | Age of subject at index date (calculated using date of birth) | Insurance registry |
| Income security benefits | Patient receives income security benefit (a proxy for socioeconomic status) | Prescription drug |
| Concurrent medications | Concurrent medications use during one year prior to subject's index date, and for the first 6 months of the study observation period. | Prescription Drug |
| Beta blockers | ||
| Angiotensin converting enzyme inhibitors | ||
| ASA | ||
| Oral hypoglycemics | ||
| Prior cardiovascular event | Cardiovascular event(s) in one year prior to subject's index date (Based in ICD-10-CA classifications) | Hospital Services |
| Myocardial infarction (I21. - I23.) | ||
| Stroke (all causes) (I60. - I64.) | ||
| Transient ischemic attack (G45.0) | ||
| Unstable angina (I20.0) | ||
| Other ischemic heart disease (I24. - I25.) | ||
| Revascularization procedures | ||
| PTCA (1.IJ.50, 1.IJ.57.GQ, 1.IL.35), CABG (1.IJ.76) | ||
| Coronary Angiography (3.IP.10) | ||
| Study cardiovascular event | Cardiovascular event(s) during study period (Based in ICD-10-CA classifications) | Hospital Services |
| Myocardial infarction (I21. - I23.) | ||
| Stroke (all causes) (I60. - I64.) | ||
| Transient ischemic attack (G45.0) | ||
| Unstable angina (I20.0) | ||
| Other ischemic heart disease (I24. - I25.) | ||
| Revascularization procedures | ||
| PTCA (1.IJ.50, 1.IJ.57.GQ, 1.IL.35), CABG (1.IJ.76) | ||
| Coronary Angiography (3.IP.10) | ||
| Chronic disease score | Chronic disease score (measure of chronic disease status derived from population-based automated pharmacy data) [37] | Prescription Drug |
| Prior hospitalizations | Number of hospitalizations in one year prior to subject's index date | Hospital Services |
| Study hospitalizations | Number of hospitalizations during study observation period | Hospital Services |
| Physician visits | Number of physician visits during and prior to observation | Physician Services |
| Pharmacy Level | ||
| Pharmacy Type | Indicates the type of pharmacy (mass merchandise, chain/grocery, independent) [38] | Investigators to categorize |
| Pharmacy Location | Rural (population < 10,000) | Investigators to categorize |
| Regional (population 10,000 - 100,000) | ||
| Urban (population > 100,000) | ||
| Prescription Volume | Mean number of new statin prescriptions filled monthly (proxy measure for prescription volume) | Prescription Drug |
| Pharmacist Coverage | Pharmacist overlap or single pharmacist | Pharmacy survey |
| Technician Support | Pharmacy technician support | Pharmacy survey |