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. 2010 Jul 1;11:363. doi: 10.1186/1471-2105-11-363

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Copyright ©2010 Mechelke and Habeck; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Structural changes viewed from different frames of reference. A: Conformations of elongation factor G sampled along the first principal component. Conformations are optimally superimposed according to RMSD because they are generated in the Eckart frame. B: The core-weighted fit aims to superimpose the structurally invariant part, irrespective of the underlying physical mechanism. Viewed from this frame of reference most of the changes happen in the C-terminal domains (domain IV and V). C: Empirical distribution of the displacements in the Eckart frame (grey) and according to the core-weighted fit (black). D: Distribution of the displacements relating the bound and unbound structure of GroEL.