Figure 2.

Effect of Pg-FET on Hz-induced MMP-9 promoter activity. Hz also induced a 2.5 fold increase of MMP-9 promoter activity, which was completely antagonized (80 and 90% inhibition) by Pg-FET at 50 and 100 μg/ml, respectively. Parthenolide (10 μM) was used as reference inhibitor of MMP-9 (~80% inhibition) promoter activity. Data are expressed as mean ± S.D. of triplicate samples. All experiments were reproduced at least three times. Statistical analyses were performed with GraphPad Prism 5 software, using 1-way ANOVA test followed by Bonferroni's post hoc test. The significance was indicated as *** p < 0.001.