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. 2010 Jul 19;9:208. doi: 10.1186/1475-2875-9-208

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Copyright ©2010 Dell'Agli et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of urolithins on MMP-9 secretion (panel A) and mRNA levels (panel B) in THP-1 cells stimulated with Hz. Urolithins A, B and 8ME at 25 μM inhibited the release of MMP-9 in Hz-stimulated THP-1 cells, urolithins A and B being the most active (-87, -37, and -74%, respectively; Panel A); the effect was associated to a decrease of MMP-9 mRNA levels (-88%, -95% and -82% respectively; Panel B). All experiments were reproduced at least three times. Statistical analyses were performed with GraphPad Prism 5 software, using 1-way ANOVA test followed by Bonferroni's post hoc test. The significance was indicated as follows: ** p < 0.01; *** p < 0.001.