. Author manuscript; available in PMC: 2010 Aug 2.

Published in final edited form as: Nat Cell Biol. 2009 Oct 18;11(11):1315–1324. doi: 10.1038/ncb1984

Table 1.

Analysis of fork rates in Top1 proficient (P388, HCT116) and Top1-deficient (45/R, shTop1 HCT116) cells exposed to Diospyrin (D1), Cordycepin (Cord.), RNaseH1 or siASF. Statistical analyses were performed with the Mann-Whitney rank sum test.

Fork rate (kb/min)	P388			45/R		HCT116			shTop1
Fork rate (kb/min)	Ctrl	D1	siASF	Ctrl	Cord.	Ctrl	D1	siASF	Ctrl	Cord.	RNaseH
Nb. values	137	146	103	141	112	122	133	108	149	118	103
Median	1.22	0.96	0.78	0.73	0.90	1.18	0.85	0.91	0.77	1.01	0.95
Mean	1.25	0.94	0.88	0.79	0.90	1.16	0.89	0.92	0.83	1.02	1.01
St. Dev.	0.41	0.34	0.36	0.29	0.29	0.31	0.28	0.27	0.34	0.32	0.39
P-value	-	^***	^***	-	^**	-	^***	^***	-	^***	^***
	-	0.06		-	-	-	0.44		-	0.34

^***

P<0.0001;

^**

P<0.001. Differences between cells treated with Diospyrin and siASF or Cordycepin and RNaseH1 are not statistically significant.