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. Author manuscript; available in PMC: 2011 Sep 6.
Published in final edited form as: Chem Biol Interact. 2010 Apr 20;187(1-3):163–166. doi: 10.1016/j.cbi.2010.04.014

Figure 2.

Figure 2

Reversible complexes of 2PAM and HI6 with native and aged AChE. Crystal structures of HI6 bound to the active center gorge of A) native mouse AChE (pdb ID 2GYU, [11]) and B) aged mouse AChE at S203 (pdb ID 2WHQ, [12]). Crystal structures of 2PAM bound to the base of the active center gorge of C) native Topedo californica AChE (pdb ID 2VQ6, [13]) and D) aged Topedo californica AChE at S200 (pdb ID 2WG1, [14]). The oxime structures are shown as a stick model. The AChE active center gorge is represented by Connolly solvent accessible surface.