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. Author manuscript; available in PMC: 2011 Sep 6.
Published in final edited form as: Chem Biol Interact. 2010 Apr 20;187(1-3):163–166. doi: 10.1016/j.cbi.2010.04.014

Table 1.

Dissociation constants (Kd) for binding of oximes to native and OP-conjugated hAChE. Constants were determined by one or more different experimental approaches described in Material and Methods section, and averaged with standard deviation lower than of 50% of Kd values.

Kd (μM)
oxime h AChE
native aged VX-inhibited POX-inhibited CS-inhibited
28B 2.0 0.23 2.5 16 ≥ 100
81A 0.40 1.6 27 63 4.8
153 1.1 5.8 16 91 ≥ 300
2PAM 150 8.7 350 ≥ 1000 ≥ 300
HI6 38 7.9 260 ≥ 1000 nd