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Interaction kinetics of 9-aminoacridine with native and OP-conjugated hAChE. The second order association constants (k1) were determined as described in Material and Methods section. The calculated standard deviation was lower than of 30% of the constant values.
| hAChE |
k1 (109 M-1min-1) |
|---|---|
| native | 6.6 |
| aged | 4.9 |
| VX-inhibited | 1.6 |
| POX-inhibited | 1.6 |
| CS-inhibited | 1.9 |
