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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Cancer Res. 2010 Jul 7;70(15):6377–6383. doi: 10.1158/0008-5472.CAN-10-1180

Figure 1. TMEPAI expression in invasive breast ductal cancers and its regulation by TGF-β signaling.

Figure 1

A. Western blot of TMEPAI in primary human patient (Pat1-4) breast tumor samples and corresponding normal/benign (N/BN1-4) samples; B. Western blot analysis for TMEPAI in invasive and non-invasive breast cancer cell lines. Asterisk (*) indicates non-specific band interacting with TMEPAI antibody. C. Effect of TGF-β and inhibition by SB431542 (SB) on TMEPAI mRNA by Q-PCR in hTERT-HME1 breast epithelial cells and MDA-MB-231 breast cancer cells and TMEPAI protein levels in MDA-MB-231 cells. D. Inhibition of Basal and TGF-β induced TMEPAI protein expression by Smad7 and DN ALk5 (i). Exogenous expression of Alk5 in MCF-7 cells restores induction of TMEPAI by TGF-β in MCF-7 cells (ii).