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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Cancer Res. 2010 Jul 7;70(15):6277–6282. doi: 10.1158/0008-5472.CAN-09-4224

Figure 4.

Figure 4

IR + ABT-888 induces persistent IRIF and senescence in vivo and suppresses MCF7Tet-On GFP-IBD tumor regrowth. A, Dose-response of IRIF formation in xenograft tumor cells 24 h after IR. Scale bar, 10 μm. B, IR + ABT-888 increases residual IRIF compared to IR alone. Intravital imaging of GFP-IBD foci in tumors at 3 and 24 h after 3 Gy ± ABT-888. Scale bar, 10 μm. C, SA-βGal activity in tumors treated with IR ± ABT-888. Frozen sections of excised tumors 7 d after IR were fixed and stained. Scale bar, 20 μm. D, ABT-888 + IR suppresses tumor regrowth. Tumor growth was significantly delayed after 6 Gy + ABT-888 (solid squares) compared to 6 Gy (solid circles). Data graphed as mean fractional volume (V/Vo) ± SEM (n = 4/group).

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