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. Author manuscript; available in PMC: 2011 Sep 6.
Published in final edited form as: Chem Biol Interact. 2010 May 20;187(1-3):124–127. doi: 10.1016/j.cbi.2010.05.007

Fig. 2.

Fig. 2

Energetic origins of β-secondary deuterium isotope effects for the formation of the tetrahedral intermediate in the acylation stage of BuChE-catalyzed hydrolysis of ATCh. Verticle arrows denote values of ΔEa, and are labeled with the corresponding isotopic reaction rate or equilibrium constant. Interpretation of isotope effects in terms of structural changes in the substrate is discussed in the text.