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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Cancer Res. 2010 Jul 20;70(15):6303–6312. doi: 10.1158/0008-5472.CAN-10-1022

Figure 1. Amphiphilic blocked polymer coated IONPs conjugated to the EGFRvIIIAb.

Figure 1

Illustration of IONP (shown in red; core size of 10 nm) coated with a biocompatible amphiphilic copolymer bioconjugated to the EGFRvIIIAb (Illustration provided by Eric Jablonowski, Dept. of Radiology, Emory University School of Medicine). Polyethylene glycols (PEG) are present on the surface of the polymer for further stabilization and biocompatibility of the IONP. Bioconjugation of the EGFRvIII antibody is performed to the –COOH of the polymer coating of the IONP.