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. 2010 May 20;6(2):201–209. doi: 10.1007/s11302-010-9183-x

Table 1.

Histological expression (mRNA and receptor protein) of P2 receptors in the cochlear partition

Subtype Species Age Target Method Findings References
IHC
P2 Guinea pig Adult Receptor Fluorescence imaging P2 receptors localized at the apical membrane [4]
P2X Guinea pig N/A Receptor Fluorescence imaging P2X ionotropic channels localized at the endolymphatic surface [5]
P2X2 Rat E12-Adult mRNA In situ hybridization Positive for P10–P12 [6]
Rat Adult Receptor Immunohistochemistry Negative [7]
Mouse N/A Receptor Immunohistochemistry Negative [8]
Guinea pig Adult Receptor Immunohistochemistry Positive at stereocilia [9]
P2X3 Rat E16-Adult Receptor Immunohistochemistry Negative [10]
Mouse E18-Adult Receptor Immunohistochemistry Slightly positive for E18 [11]
P2X7 Rat E14-Adult Receptor Immunohistochemistry Positive for P0–P6 [12]
 
SGN (type I)
P2 Guinea pig Adult Receptor Autoradiography Positive [13]
P2X1–P2X6 Rat Adult Receptor Immunohistochemistry All positive, strongest in P2X2 [14]
P2X1 Rat E12-Adult mRNA In situ hybridization Positive for E16–P6 [15]
P2X2 Mouse N/A Receptor Immunohistochemistry Positive [8]
Rat P7-Adult Receptor Immunohistochemistry All positive, strongest at synaptic region under IHC [16]
Guinea pig Adult Receptor Immunohistochemistry Positive at postsynaptic membrane under IHC [9]
mRNA RT-PCR P2X2–2 is the dominant splice variant
Rat E16-Adult Receptor Immunohistochemistry Positive, stronger at the synaptic region for E19–P6 [7]
Rat Adult mRNA In situ RT-PCR Positive for a subpopulation of SGNs [17]
mRNA RT-PCR Identification of the third isoform, P2X2-3
Rat E12-Adult mRNA In situ hybridization Positive for E16-Adult, maximum at P8-P12 [6]
P2X3 Rat E16-Adult Receptor Immunohistochemistry Neuron body: positive for E16–P14 [10]
Afferent fibers: positive for E18–P4
Mouse E18-Adult Receptor Immunohistochemistry Positive (body and fibers) for E18–P6 [11]
P2X7 Rat E14-Adult Receptor Immunohistochemistry Positive in neuron body for E18-Adult [12]
Positive at synaptic region under IHC for P0-Adult