Table 4.
P2 conductances in SGN (type I) and VGN
| P2X conductance | P2Y conductance | ||||
|---|---|---|---|---|---|
| SGN [32, 33] | Desensitizing cation nonselective conductance | VGN [40] | Desensitizing cation nonselective conductance | SGN [33] | Large pore conductance that passes NMDG+ and TEA+ |
| Impermeable to large cations as NMDG+ | Impermeable to large cations as NMDG+ | Activation of a common pathway with ACh and SP | |||
| ATP ≈ ADP > alpha, beta-me ATP > 2-MeS ATP | ATP > alpha, beta-me ATP > ADP | Sensitivity to pretreatment of ionomycin | |||
| Decay time constant tau ≈2 s | Decay time constant tau =2–4 s | ||||
| Recovery after desensitization in 4 min | Recovery after desensitization in 3 min | ||||
| Augmentation with lower pH | No effect with lower pH | ||||