Table 1.
Comparisons of comorbidities, anthropometric parameters and cardiovascular risk biomarkers between patients with acromegaly (n = 81) and the age- and gender-matched DETECT-controls (n = 320)
| Patients with acromegaly (n = 81) | DETECT-control group (n = 320) | P-value | |||
|---|---|---|---|---|---|
| n | % | n | % | ||
| Comorbidities | |||||
| Hypertension | 44 | 54.3 | 121 | 37.8 | 0.008 |
| Diabetes mellitus | 22 | 27.2 | 58 | 18.1 | 0.073 |
| Coronary heart disease | 7 | 8.6 | 30 | 9.4 | 0.840 |
| Myocardial infarction | 1 | 1.2 | 11 | 36.7 | 0.001 |
| Cerebral insult | 4 | 4.9 | 0 | 0.0 | – |
| Malignancies | 9 | 11.1 | 10 | 3.1 | 0.005 |
| Pituitary deficiency | 48 | 59.3 | |||
| Corticotrope deficiency | 35 | 43.2 | |||
| Thyreotrope deficiency | 22 | 27.2 | |||
| Gonadotrope deficiency | 33 | 40.7 | |||
| Growth hormone deficiency | 3 | 3.7 | |||
| Mean (SD) | Mean (SD) | P-value | |
|---|---|---|---|
| Anthropometric parameters | |||
| Height (cm) | 172.4 (12.0) | 170.1 (9.3) | 0.107 |
| Weight (kg) | 86.6 (17.8) | 79.8 (17.4) | 0.002 |
| BMI (kg/m2) | 29.2 (5.2) | 27.5 (5.6) | 0.014 |
| Waist circumference (cm) | 100.0 (14.3) | 95.7 (15.5) | 0.026 |
| Hip circumference (cm) | 110.6 (9.2) | 105.6 (12.0) | 0.001 |
| Waist to height ratio | 0.58 (0.09) | 0.56 (0.09) | 0.174 |
| Biochemical parameters | |||
| IGF-1 (μg/L) | 214.2 (161.2) | 131.5 (54.3) | 0.000 |
| Cardiovascular risk biomarkers | |||
| Fasting plasma glucose (mg/dL) | 93.5 (16.5) | 104.1 (35.1) | 0.001 |
| HbA1c (%) | 5.7 (0.5) | 5.6 (1.0) | 0.550 |
| Total cholesterol (mg/dL) | 215.8 (39.5) | 226.6 (44.0) | 0.045 |
| Triglycerides (mg/dL) | 121.1 (63.6) | 160.8 (155.3) | 0.001 |
| HDL (mg/dL) | 60.4 (21.4) | 53.0 (17.6) | 0.009 |
| LDL (mg/dL) | 139.4 (37.4) | 131.0 (32.4) | 0.093 |
| Lipoprotein (a) (mg/dL) | 36.1 (43.5) | 33.3 (47.3) | 0.707 |
Note: Significant effects are bold typed