Table 3.
Comparisons of comorbidities, anthropometric parameters and cardiovascular risk biomarkers between acromegalic patients with (n = 22) and without diabetes mellitus (n = 59) and the age- and gender-matched DETECT-controls (n = 88 and n = 232, respectively)
| Patients with acromegaly and no diabetes mellitus + (n = 59) | Patients with acromegaly and diabetes mellitus (n = 22) | P-value no diabetes versus diabetes | DETECT-control group, patients with no diabetes (n = 232) | P-value versus no diabetes | DETECT-control group, patients with diabetes (n = 88) | P-value versus diabetes | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | n | % | ||||
| Comorbidities | |||||||||||
| Hypertension | 29 | 49.2 | 15 | 68.2 | 0.133 | 88 | 37.9 | 0.007 | 33 | 37.5 | 0.715 |
| Diabetes mellitus | – | – | – | – | 42 | 18.1 | – | 16 | 18.2 | – | |
| Coronary heart disease | 5 | 8.5 | 2 | 9.1 | 0.930 | 24 | 10.3 | 0.437 | 6 | 6.8 | 0.130 |
| Myocardial infarction | 1 | 1.7 | 0 | 0.0 | – | 7 | 29.2 | 0.002 | 4 | 66.7 | – |
| Cerebral insult | 1 | 1.7 | 3 | 13.6 | 0.063 | 0 | 0.0 | – | 0 | 0.0 | – |
| Malignancies | 6 | 10.2 | 3 | 13.6 | 0.662 | 7 | 3.0 | 0.015 | 3 | 3.4 | 0.227 |
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | ||||
|---|---|---|---|---|---|---|---|
| Anthropometric parameters | |||||||
| Height (cm) | 174.7 (12.1) | 166.0 (9.1) | 0.001 | 171.1 (9.2) | 0.006 | 167.3 (9.0) | 0.060 |
| Weight (kg) | 87.3 (17.7) | 84.6 (18.6) | 0.559 | 80.5 (17.1) | 0.000 | 77.7 (18.2) | 0.449 |
| BMI (kg/m2) | 28.6 (4.8) | 30.7 (6.2) | 0.155 | 27.5 (5.3) | 0.015 | 27.6 (6.1) | 0.831 |
| Waist circumference (cm) | 98.9 (10.9) | 102.8 (21.4) | 0.449 | 96.3 (15.9) | 0.003 | 93.8 (14.3) | 0.596 |
| Hip circumference (cm) | 110.8 (8.7) | 110.2 (10.7) | 0.830 | 105.6 (12.1) | 0.000 | 105.6 (11.9) | 0.829 |
| Waist to height ratio | 0.57 (0.06) | 0.61 (0.13) | 0.131 | 0.56 (0.09) | 0.127 | 0.56 (0.08) | 0.870 |
| Biochemical parameters | |||||||
| IGF-1 (μg/L) | 218.6 (152.6) | 202.7 (185.5) | 0.720 | 135.4 (56.2) | 0.000 | 121.4 (48.0) | 0.057 |
| Cardiovascular risk biomarkers | |||||||
| Fasting plasma glucose (mg/dL) | 89.9 (11.9) | 103.6 (22.8) | 0.010 | 104.3 (36.8) | 0.011 | 103.5 (30.2) | 0.000 |
| HbA1c (%) | 5.6 (0.4) | 5.9 (0.6) | 0.038 | 5.6 (1.0) | 0.000 | 5.7 (0.9) | 0.000 |
| Total cholesterol (mg/dL) | 214.3 (39.0) | 219.8 (41.7) | 0.616 | 227.1 (45.9) | 0.031 | 225.3 (38.9) | 0.787 |
| Triglycerides (mg/dL) | 107.1 (54.4) | 157.3 (72.5) | 0.007 | 158.8 (128.2) | 0.000 | 166.2 (211.8) | 0.071 |
| HDL (mg/dL) | 59.9 (21.8) | 61.7 (20.8) | 0.748 | 52.9 (18.0) | 0.095 | 53.3 (16.5) | 0.010 |
| LDL (mg/dL) | 139.7 (37.0) | 138.7 (39.4) | 0.920 | 131.4 (33.5) | 0.195 | 130.2 (29.4) | 0.209 |
| Lipoprotein (a) (mg/dL) | 45.6 (48.8) | 13.8 (8.5) | 0.003 | 31.6 (44.3) | 0.282 | 37.6 (54.7) | 0.021 |
Note: Significant effects are bold typed