Histograms showing the mean values of body weights (BW, g) recorded from all animal groups at four different times: (1) at the start of the experiment (before ovariectomy), (2) 2 months after ovariectomy, (3) after 30 days of treatment and (4) after 60 days of treatment. Values are expressed as mean ± SEM. ***P< 0.001 vs. C-OVX; ###P< 0.001 vs. SHAM (anova followed by Newman–Keuls test). SHAM, sham-operated controls receiving vehicle; C-OVX, ovariectomized controls receiving vehicle; F-OVX, ovariectomized treated with ferutinin; EB-OVX, ovariectomized treated with estradiol benzoate; BW, body weight.