Mean values of histomorphometric parameters, expressed as BV/TV (%) and Ct-B-Ar (mm²), in both trabecular and cortical bone of the four animal groups, 2 months after OVX and at the end of 60 days of treatment.

	4th lumbar vertebra sagittal sections BV/TV (%)	5th lumbar vertebra transversal sections BV/TV (%)	Femur sagittal sections of distal epiphysis BV/TV (%)	Femur transversal sections of mid-diaphysis Ct-B-Ar (mm2)
SHAM	42.8 ± 3.5	29.7 ± 1.0	46.6 ± 2.6	5.798 ± 0.311
C-OVX	27.5 ± 1.1###	14.6 ± 2.0###	11.1 ± 1.5###	6.135 ± 0.188
F-OVX	38.7 ± 1.6**	19.5 ± 2.3##	21.8 ± 2.8###,**	6.087 ± 0.105
EB-OVX	33.8 ± 1.6#,*	22.9 ± 1.7#,*	24.6 ± 3.2###,**	6.002 ± 0.179

Values are expressed as mean ± SEM.

^*P< 0.05

^**P < 0.01 vs. C-OVX;

^#P< 0.05

^##P< 0.01

^###P< 0.001 vs. SHAM (anova followed by Newman–Keuls test).

SHAM, sham-operated controls receiving vehicle; C-OVX, ovariectomized controls receiving vehicle; F-OVX, ovariectomized treated with ferutinin; EB-OVX, ovariectomized treated with estradiol benzoate.