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Endothelium-dependent vasodilation in healthy and diabetic subjects. A, The increase in FBF induced by incremental methacholine from baseline during placebo and ruboxistaurin treatment is shown. Endothelium-dependent vasodilation in subjects with diabetes (•) was attenuated when compared with healthy control subjects (▪) (P = 0.001). Ruboxistaurin did not affect endothelium-dependent vasodilation in either healthy or diabetic subjects. NS, Not significant.
