Table 1.
Baseline clinical and electrocardiography characteristics and 30-day mortality in patients with different aVR ST levels
| Lead aVR |
P-value | ||
|---|---|---|---|
| ST↑ ≥1 mm | No ST ↑ ≥1 mm | ||
| Anterior AMI group (n = 7664) | n = 779 | n = 6885 | |
| Demographics | |||
| Age (years) (IQR) | 64 (54–72) | 61 (51–70) | <0.0001 |
| Women (%) | 257 (33.0) | 1928 (28.0) | 0.0035 |
| History of cardiac disease | |||
| Angina (%) | 476 (61.1) | 3358 (48.8) | <0.0001 |
| Myocardial infarction (%) | 164 (21.1) | 1049 (15.2) | <0.0001 |
| Risk factors | |||
| Hypertension (%) | 461 (59.2) | 3580 (52.0) | <0.0001 |
| Diabetes (%) | 100 (12.8) | 941 (13.7) | 0.5214 |
| Smoking history | |||
| Never smoked (%) | 353 (45.3) | 2802 (40.7) | 0.0302 |
| Past smoker (%) | 130 (16.7) | 1157 (16.8) | |
| Current smoker (%) | 296 (38.0) | 2926 (42.5) | |
| Time from symptom onset to randomization | |||
| ≤2 h (%) | 167 (21.4) | 1323 (19.2) | 0.0803 |
| >2 but ≤4 h (%) | 404 (51.9) | 3475 (50.5) | |
| >4 h (%) | 208 (26.7) | 2085 (30.3) | |
| Haemodynamics | |||
| Systolic blood pressure (IQR) (mmHg) | 140 (120–150) | 139 (120–150) | 0.9033 |
| Diastolic blood pressure (IQR) (mmHg) | 80 (74–90) | 80 (75–90) | 0.8419 |
| Heart rate (IQR) (b.p.m.) | 82 (72–94) | 80 (69–90) | <0.0001 |
| Killip class | |||
| I (%) | 540 (69.3) | 5262 (76.4) | <0.0001 |
| II (%) | 185 (23.8) | 1360 (19.8) | |
| III (%) | 42 (5.4) | 185 (2.7) | |
| IV (%) | 12 (1.5) | 78 (1.1) | |
| Summed ST elevationa (IQR) (mm) | 12 (8–12) | 15.5 (10–23.5) | <0.0001 |
| Summed ST depressiona (IQR) (mm) | 6 (3.5–8.5) | 1.5 (0.5–3) | <0.0001 |
| 30-day mortality | 121 (15.5%) | 837 (12.2%) | 0.0069 |
| Without RBBB (n = 7299) (%) | 110 (14.7) | 735 (11.2) | 0.0045 |
| With RBBB (n = 365) (%) | 11 (34.4) | 102 (30.6) | 0.6617 |
| Inferior AMI group (n = 8161) | n = 365 | n = 7796 | |
| Demographics | |||
| Age (years) (IQR) | 66 (57–73) | 60 (51–69) | <0.0001 |
| Women (%) | 179 (49.0) | 2086 (26.8) | <0.0001 |
| History of cardiac disease | |||
| Angina (%) | 243 (66.6) | 3304 (42.4) | <0.0001 |
| Myocardial infarction (%) | 117 (32.1) | 966 (12.8) | <0.0001 |
| Risk factors | |||
| Hypertension (%) | 250 (68.5) | 3842 (49.3) | <0.0001 |
| Diabetes (%) | 81 (22.2) | 1057 (13.6) | <0.0001 |
| Smoking history | |||
| Never smoked (%) | 200 (54.8) | 2723 (34.9) | <0.0001 |
| Past smoker (%) | 56 (15.3) | 1366 (17.5) | |
| Current smoker (%) | 109 (29.9) | 3707 (47.6) | |
| Time from symptom onset to randomization | |||
| ≤2 h (%) | 51 (14.0) | 1777 (22.8) | <0.0001 |
| >2 but ≤4 h (%) | 187 (51.2) | 3921 (50.3) | |
| >4 h (%) | 127 (34.8) | 2093 (26.9) | |
| Haemodynamics | |||
| Systolic blood pressure (IQR) (mmHg) | 140 (120–150) | 130 (120–150) | 0.0010 |
| Diastolic blood pressure (IQR) (mmHg) | 80 (70–90) | 80 (70–90) | 0.0605 |
| Heart rate (IQR) (b.p.m.) | 80 (70–97) | 72 (62–84) | <0.0001 |
| Killip class | |||
| I (%) | 246 (67.4) | 6565 (84.2) | <0.0001 |
| II (%) | 84 (23.0) | 1061 (13.6) | |
| III (%) | 25 (6.9) | 87 (1.1) | |
| IV (%) | 10 (2.7) | 83 (1.1) | |
| Summed ST elevationa (IQR) (mm) | 5 (3–7.5) | 8 (5–12) | <0.0001 |
| Summed ST depressionb (IQR) (mm) | 12 (7.5–17.5) | 6.5 (3.5–11.5) | <0.0001 |
| 30-day mortality | 58 (15.9%) | 509 (6.5%) | <0.0001 |
| Without RBBB (n = 8016) (%) | 58 (16.0) | 492 (6.4) | <0.0001 |
| With RBBB (n = 145) (%) | 0 | 17 (12.0) | 1.0000 |
aSummed ST elevation refers to ST elevation.
bSummed ST depression refers to ST depression in the other 11 ECG leads other than lead aVR.