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. 2010 Jul 28;16:1415–1428.

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Copyright © 2010 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Inner limiting membrane disruptions during early eye development in protein O-mannose N-acetylglucosaminyltransferase 1 (POMGnT1) knockout mice. Electron microscopic analysis was performed on the developing retinas at embryonic day 11.5 (A and B), embryonic day 13.5 (C and D), and embryonic day 15.5 (E and F). A, C, and E are from wildtype retinas. B, D, and F are from knockout retinas. Note the broken inner limiting membrane at E13.5 (arrow in D) and the absence of the inner limiting membrane at E15.5 (asterisks in F) in POMGnT1 knockout mouse retina. The scale bar in D is equal to 500 nm. +/+ represents wild type; −/− represents homozygous knockout.