Table 1.

Univariate and multivariate analysis of survival in patients with chronic myeloid leukemia in the Patterns of Care study using Cox proportional hazards. Use of imatinib and age were the major determinants of survival.

Characteristic	Strata	Univariate Analysisa		Multivariate Analysisb
		Hazard Ratio	95 percent Confidence Interval	Hazard Ratio	95 percent Confidence Interval
Imatininb	Yes	1.0	Reference	1.0	Reference
	No	4.1c	2.7, 6.2	2.7c	1.7, 4.2
Sex	Male	1.0	Reference	1.0	Reference
	Female	0.8	0.5, 1.2	0.7	0.5, 1.1
Ancestry	Non Hispanic	1.0	Reference	1.0	Reference
	Black	1.0	0.6, 2.0	1.4	0.8, 2.7
	Hispanic White	0.6	0.3, 1.3	1.0	0.5, 2.1
	Other	0.9	0.4, 2.2	1.3	0.5, 3.1
Marital Status	Never Married	1.0	Reference	1.0	Reference
	Married	0.9	0.5, 1.6	0.6	0.3, 1.0
	Separated/Divorced	0.7	0.3, 1.6	0.5	0.2, 1.2
	Widowed	1.9	0.9, 3.9	0.5	0.2, 1.1
	Unknown	0.7	0.3, 1.9	0.4	0.1, 1.1
Age at Diagnosis (Years)	20–59	1.00	Reference	1.00	Reference
	60–79	2.6c	1.5, 4.3	2.3c	1.3, 3.8
	80+	7.8c	4.5, 13.5	5.3c	3.0, 9.5
Income (Quartiles)	First (Low)	1.0	Reference	1.0	Reference
	Second	0.9	0.5, 1.6	1.0	0.5, 1.7
	Third	0.8	0.5, 1.5	0.8	0.4, 1.4
	Fourth (High)	0.7	0.4, 1.3	0.7	0.4, 1.3
Education (Quartiles)	First (Low)	1.0	Reference	1.0	Reference
	Second	1.1	0.6, 2.0	0.9	0.5, 1.6
	Third	1.2	0.7, 2.2	1.1	0.6, 1.9
	Fourth (High)	0.9	0.5, 1.6	0.8	0.4, 1.4
Residence	Urban	1.0	Reference	1.0	Reference
	Rural	2.0	0.6, 6.1	2.4	0.8, 6.8
Insurance	Yes	1.0	Reference	1.0	Reference
	No	0.1	0.0, 1.1	0.3	0.0, 2.0
	Unknown	0.4	0.1, 1.3	0.5	0.2, 1.4
One or more co morbidities	No	1.0	Reference	1.0	Reference
	Yes	1.1	0.6, 2.1	1.3	0.7, 2.6

^aCalculated by univariate Cox proportional hazards model

^bCalculated by multivariate Cox proportional hazards model, adjusting for receipt of imatinib and age at diagnosis

^cHazards ratio significantly different from unity (i.e., 1.00), p<0.005