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. Author manuscript; available in PMC: 2011 Jul 30.
Published in final edited form as: Mol Cell. 2010 Jul 30;39(2):209–221. doi: 10.1016/j.molcel.2010.06.021

Figure 6. Model for PoxA, YjeK and EF-P function.

Figure 6

The eIF5A protein is modified at a conserved lysyl residue by two enzymes to generate the unique amino acid hypusine, which is required for cell growth and viability in eukaryotes. See (Park, 2006) for a review of the hypusine biosynthesis pathway. PoxA catalyzes aminoacylation (with lysine) of the same conserved lysyl residue of EF-P (see Figure 4). YjeK, a 2,3-β-lysine aminomutase, is shown here modifying the Lys-Lys side-group to generate a fully active form of EF-P. Alternatively, YjeK may act on the lysine substrate prior to its ligation to EF-P.