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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Mol Pharm. 2009 Mar-Apr;6(2):10.1021/mp800264k. doi: 10.1021/mp800264k

Figure 9.

Figure 9

NIR confocal microscopy of A549 cells transfected with compound 5. Top panel: The confocal fluorescence image of 5 in the cytoplasm of A549 cells before (a–d) and after (e–h) 5μM paclitaxel activation of caspase-3 for 2h at 37°C. Nuclei and compound 5 were colored blue and red, respectively. The scale bar is 30 μm for a–g and 15μm for h (to amplify the visual distribution of the probe in cells). Bottom panel: Quantitative analysis of the fluorescent intensity in the cytoplasm of A549 cells transfected with compound 5 before and after caspase-3 activation with 5μM paclitaxel for 2 h at 37°C ( p< 0.05). Control was not transfected with compound 5 before treatment with paclitaxel.