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. 2010 Aug 4;99(3):897–904. doi: 10.1016/j.bpj.2010.04.070

Figure 7.

Figure 7

BMP signaling model including CK2-β. Shown here is an incorporation of CK2-β with the model for activation of BMP signaling. CK2-β (gray ovals) binds to preformed complexes of BRIa and BRII. There is a release of CK2-β from BRIa upon stimulation of BMP2 (pentagons). BRII phosphorylates BRIa, and BRIa then phosphorylates Smad 1/5/8. Smad4 forms a complex with phosphorylated Smad1/5/8 and translocates to the nucleus, where it regulates gene transcription and downstream effects (which would include mineralization).