Table 2.
Predictors of severe fibrosis (Ishak fibrosis 4–6) by backward stepwise multinomial regression. Input variables were gender, previous CMV or HBV, age, BMI, CD4+CD45RO+ telomere length, and CD8+CD45RO+ telomere length. Variables associated with severe fibrosis (p <0.1) in simple linear regression were included in a multiple regression analysis.
| Variable | Simple multinomial regression |
Backward stepwise multinomial regression |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| β | SE | df | OR (95% CI) | p | β | SE | df | OR (95% CI) | p | |
| Male gender | 0.89 | 0.44 | 1 | 2.43 (1.03, 5.74) | 0.043 | 1.04 | 0 .50 | 1 | 2.84 (1.07, 7.53) | 0.04 |
| CMV+ | 1.33 | 0.44 | 1 | 3.78 (1.61, 8.83) | 0.002 | 1.43 | 0 .48 | 1 | 4.18 (1.63, 10.73) | 0.003 |
| Age | 0.07 | 0.02 | 1 | 1.08 (1.03, 1.12) | 0.001 | |||||
| BMI | 0.02 | 0.04 | 1 | 1.02 (0.94, 1.10) | 0.71 | |||||
| Anti-HBc+ | 1.65 | 0.54 | 1 | 5.20 (1.80, 15.1) | 0.002 | 1.58 | 0 .58 | 1 | 4.74 (1.53, 14.72) | 0.007 |
| CD4+CD45RO+ telomere length | 0.05 | 0.01 | 1 | 1.05 (1.02, 1.08) | 0.001 | 0.04 | 0 .01 | 1 | 1.05 (1.02, 1.78) | 0.003 |
| CD8+CD45RO+ telomere length | 0.03 | 0.01 | 1 | 1.03 (1.01, 1.06) | 0.002 | |||||
Bold indicates significant results.