Figure 6.
Targeted gene knockdown of cx43 restores joint formation in alf dty86 fins. (A) Segment length in alf dty86 fins following cx43 gene knockdown (alf KD) is similar to segment length following cx43 gene knockdown in wild-type fins (wt KD). Results of gene knockdown in both wild-type and alf dty86 are statistically different from wild-type fins treated with a non targeting morpholino (p ≪ 0.05). Wild-type and alf dty86 knockdown fins are not statistically different from one another. (B) Joints (arrows) are observed in each of three alf dty86 fin rays treated with cx43-MO2.