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Endothelium-dependent dilation (during control acetylcholine and inhibition of nitric oxide synthesis with Ng-monomethyl L-arginine [L-NMMA]) and endothelium-independent dilation (forearm blood flow responses to intra-brachial artery infusion of acetylcholine and sodium nitroprusside, respectively) at baseline and after weight loss (16 weeks; n=15). Values are mean ± SE. *P<0.05 vs. baseline; †P<0.05 dose × time interaction; FAV=forearm volume.
