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. 2010 Jul;2(7):258–274. doi: 10.1002/emmm.201000079

Figure 7. ADFP, ACSL1, and SapC in Mtb-infected murine and human macrophages.

Figure 7

Murine bone marrow-derived macrophages infected with Mtb H37Rv for 24hr and examined by confocal microscopy.

A, B. Expression of Adfp in (A) control cells versus (B) Mtb-infected cells.

C, D. Expression of Acsl1 in (C) control and (D) Mtb-infected macrophages.

E, F. Expression of SapC in (E) control and (F) Mtb-infected macrophages. Blue, nuclei, Green: antigens. Human PBMC-derived macrophages were infected by Mtb H37Rv for 4 days, and the antigens were detected by confocal microscope.

G, H. ADFP is expressed and is associated tightly with lipid droplets (G) control and (H) Mtb-infected macrophages. Lipid droplets were observed in both uninfected and infected human PBMC-derived macrophages.

I, J. ACSL1 is also detected in association with lipid droplets, (I) control and (J) Mtb-infected macrophages.

K, L. SapC is expressed and localizes throughout the cytoplasm (K) control and (L) Mtb-infected macrophages. Blue: nuclei, red: antigens, green: lipid droplets.