Table 1.
Genes encoding enzymes involved in lipid metabolism
| Gene | Description | Hierarchical signal intensitya | Fold changeb | Function |
|---|---|---|---|---|
| ABHD5 | Abhydrolase domain containing 5 | 9.6 | 34.3 | Triacylglycerol metabolism |
| ACLY | ATP citrate lyase | 12.4 | 22.7 | Acetyl-CoA synthesis |
| ACSL1 | Acyl-CoA synthetase long chain fatty acid family member 1 | 12.7 | 39.4 | Fatty acyl-CoA ester synthesis |
| ACSL3 | Acyl-CoA synthetase long chain fatty acid family member 3 | 11.1 | 71.2 | Fatty acyl-CoA ester synthesis |
| ACSL4 | Acyl-CoA synthetase long chain fatty acid family member 4 | 10.5 | 261.5 | Fatty acyl-CoA ester synthesis |
| ACSL5 | Acyl-CoA synthetase long chain fatty acid family member 5 | 11.7 | 75.5 | Fatty acyl-CoA ester synthesis |
| ADFP | Adipose differentiation-related protein | 13.1 | 19.1 | Lipid accumulation |
| CRAT | Carnitine O-acetyltransferase | 10.6 | 14.8 | Acyl-CoA/CoA regulation |
| CYP1B1 | Cytochrome P450, family 1, subfamily B, polypeptide 1 | 13.6 | 36.5 | Sterol synthesis |
| CYP27A1 | Cytochrome P450, family 27, subfamily A, polypeptide 1 | 12.6 | 48.0 | Sterol synthesis |
| DEGS1 | Degenerative spermatocyte homologue 1, lipid desaturase | 11.8 | 180.2 | Unsaturated fatty acid synthesis |
| DHCR7 | 7-Dehydrocholesterol reductase | 10.0 | 8.8 | Cholesterol synthesis |
| EBP | Emopamil binding protein | 10.4 | 18.3 | Cholesterol synthesis |
| ELOVL5 | Elovl family member 5, elongation of long chain fatty acids | 12.4 | 36.8 | Fatty acid synthesis |
| FADS1 | Fatty acid desaturase 1 | 12.2 | 45.0 | Fatty acid synthesis |
| FDPS | Farnesyl diphosphate synthase | 11.2 | 8.6 | Cholesterol synthesis |
| GBA | Glucosidase, beta, acid | 11.6 | 32.0 | Sphingolipid metabolism |
| GLA | Galactosidase, alpha | 13.0 | 152.5 | Sphingolipid metabolism |
| GLB1 | Galactosidase, beta 1 | 11.4 | 19.9 | Sphingolipid metabolism |
| GPD2 | Glycerol-3-phosphate dehydrogenase 2 | 10.2 | 60.9 | Glycerophospholipid metabolism |
| HADHA | Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase, alpha subunit | 11.0 | 16.7 | Fatty acid metabolism |
| HMGCR | 3-Hydroxy-3methylglutaryl-Coenzyme A reductase | 8.9 | 38.4 | Cholesterol synthesis |
| IDI1 | Isopentenyl-diphosphate delta isomerase 1 | 10.9 | 7.3 | Cholesterol synthesis |
| LIPA | Lipase A, lysosomal acid, cholesterol esterase | 12.6 | 209.6 | Sterol metabolism |
| LSS | Lanosterol synthase | 11.0 | 8.1 | Cholesterol synthesis |
| PLSCR1 | Phospholipid scramblase 1 | 11.8 | 137.1 | Regulation of lipid accumulation |
| PSAP | Prosaposin (precursor of sapC) | 14.6 | 30.0 | Sphingolipid metabolism |
| SCD | Stearoyl-CoA desaturase | 13.1 | 76.8 | Fatty acid synthesis |
| SC5DL | Sterol-C5-desaturase | 10.1 | 18.7 | Cholesterol synthesis |
| SOAT1 | Sterol O-acyltransferase 1 | 10.3 | 47.2 | Cholesterol esterification |
| SPHK2 | Sphingosine kinase 2 | 11.6 | 32.1 | Sphingolipid metabolisum |
| TPI1 | Triosephosphate isomerase 1 | 12.4 | 10.9 | Fatty acid synthesis |
a
Gene expression profiles from three independent caseous human TB granulomas were averaged, and the hierarchy of the absolute expression levels was generated.
b
Gene expression profiles from three independent caseous human TB granulomas were averaged, and then compared to that of normal lung tissue sample. The upregulation of selected genes were statistically significant (P < 0.05).