Table 7.

Division of the developmental toxicity data set according to the FDA Guidelines and CAESAR binary classes

FDA classes	Definition	CAESAR Binary class	Total compounds
Category A	Negative human studies
Category B	Negative animal studies
	No human studies executed	Non-developmental toxicant	91
	OR
	Positive animal studies
	Negative human studies
Category C	Positive animal studies
	No human studies executed
	OR
	No studies at all
Category D	Positive human studies	Developmental toxicant	201
Category X	Animal OR human studies show abnormalities
	AND/OR
	Evidence of fetal risk based on human experience
			292