Table 1.
Clinical and Biological Characteristics of the Hypophosphatemic Patients at the Time of Tooth Extraction
| Patient | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
|---|---|---|---|---|---|---|---|
| Sex | M | M | M | F | M | M | F |
| Age (years)* | 5 | 3 | 5 | 6 | 9 | 14.5 | 27 |
| Treatment | + | + | + | + | + | + | + |
| Age at onset (years) | 2 | 1.5 | 2.75 | 3.5 | 4.8 | 0.25 | 4.5 |
| Duration (years) | 3 | 1.5 | 2.5 | 2.5 | 4.2 | 14† | 22.5 |
| Unalfa (μg/day) | 1.5 | 1.2 | 2.5 | 1.5 | 1 | 1.5 | 1–3 |
| Phosphates (mg/kg/day) | 64 | 64 | 45 | 34 | 36 | 30 | 50 |
| Compliance | Good | Good | Good | Good | Good | Bad | Good |
| Signs of rickets | |||||||
| Leg bowing | + | ++ | ++ | + | 0 | +++ | 0 |
| Height (SD) | −1 | −3 | −3 | −1 | −2 | 0 | −3 |
| Serum phosphate (mmol/L) | 0.93 | 0.93 | 0.69 | 0.85 | 0.88 | 0.77 | 0.52 |
| Dental status | |||||||
| DMFT or dft‡ | 7 | 8 | 5 | 2 | 6 | 5 | 7 |
| Collected tooth | 51, 61, 82 | 51 | 51, 61, 74 | 52, 61 | 53, 63 | 16, 26, 36, 46 | 38 |
| Type§ | D | D | D | D | D | P | P |
| Pulp status | Vital | Necrotic | Necrotic | Necrotic + vital | Necrotic | Endo tt¶ | Vital |
Heights are given in SD regarding reference curves for sex- and age-matched healthy children. All serum phosphate concentrations were below normal for the age.
*
Age at the time of tooth collection.
†
The treatment of this child was irregularly followed from the beginning to 6 years, then stopped, and started again at 10 years.
‡
DMFT, decayed, missing, filled permanent tooth; dft, decayed, filled primary tooth.
§
Type of collected tooth, deciduous (D) or permanent (P).
¶
These teeth have been endodontically treated after decay and then extracted for orthodontic reasons.
M, male; F, female.