Table 1.

miRNAs that Trend Monotonically during SM Differentiation

miRNA	FDR	FC	Chr. location	Overlapping transcripts
hsa-miR-181c	0.0000000	8.50	19p13	Intergenic
hsa-miR-204	0.0000007	8.30	9q21	TRPM3
hsa-miR-181a	0.0000000	8.07	1q31 (a-1), 9q33 (a-2)	RP11-31E23.1 (a-1), RP11-348K2.1 (a-2, sense), NR6A1 (a-2, antisense)
hsa-miR-34a	0.0000001	6.73	1p36	Intergenic
hsa-miR-373*	0.0000001	6.61	19q13	Intergenic
hsa-miR-34b	0.0000004	5.57	11q23	Intergenic
hsa-miR-498	0.0000152	3.61	19q13	Intergenic
hsa-miR-663	0.0000275	3.59	20p11	RP3-410C9.1
hsa-miR-542-5p	0.0000068	3.04	Xq26	Intergenic
hsa-let-7b	0.0001959	2.72	22q13	RP4-695O20__B.10
hsa-miR-152	0.0007280	2.37	17q21	COPZ2
hsa-miR-324-5p	0.0001593	2.03	17p13	ACADVL
hsa-miR-93	0.0000616	−2.30	7q22	MCM7
hsa-miR-155	0.0007701	−2.51	21q21	MIRHG2
hsa-miR-202	0.0000001	−2.57	10q26	RP13-49I15.3
hsa-miR-431	0.0000275	−2.59	14q32	RTL1
hsa-miR-376b	0.0000603	−2.82	14q32	Intergenic
hsa-miR-323	0.0007280	−2.89	14q32	Intergenic
hsa-miR-758	0.0000000	−2.94	14q32	Intergenic
hsa-miR-130b	0.0000023	−3.09	22q11	PPIL2 (sense), TOP3B (antisense)
hsa-miR-625	0.0000025	−3.31	14q23	FUT8
hsa-miR-106a	0.0000001	−3.37	Xq26	Intergenic
hsa-miR-92b	0.0001959	−3.43	1q22	Intergenic
hsa-miR-20a	0.0006004	−3.50	13q31	MIRHG1
hsa-miR-409-3p	0.0000053	−3.75	14q32	Intergenic
hsa-miR-17-5p	0.0000018	−4.24	13q31	MIRHG1
hsa-miR-138	0.0000002	−5.78	3p21 (−1), 16q12 (−2)	Intergenic (−1, −2)
hsa-miR-18a	0.0000616	−5.90	13q31	MIRHG1
hsa-miR-224	0.0000715	−6.90	Xq28	GABRE
hsa-miR-7	0.0005677	−10.38	9q21 (−1), 15q25 (−2), 19p13 (−3)	HNRNPK (−1), Intergenic (−2), C19orf30 (−3)

A trend test identified 30 miRNAs that monotonically trend up or down during SM differentiation. False discovery rate (FDR) cutoff was set at 0.001. FC indicates fold change between t = 0 and the end time point. Chromosomal and intra/intergenic locations are also indicated. 

^*denotes a miRNA derived from the antisense strand.