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. 2010 Aug;177(2):1017–1030. doi: 10.2353/ajpath.2010.091105

Figure 6.

Figure 6

Matrix-metalloprotease (MMP) expression and activity in remodeling arterioles. MMP-9 (A, D, G; green) and cell markers [red: α-SMA marking VSMC of early remodeling arterioles (B), CD56 marking uNK cells in the vascular wall of actively remodeling arterioles (E), and CK marking enEVTs of advanced remodeling arterioles (H)] all demonstrate colocalization (arrowheads in C, F, and I, respectively; yellow). MMP-9 was also expressed by decidual stromal cells (st). J: Negative control for dual immunofluorescence (anti-mouse FITC and DAPI). K and N: In situ zymography revealed gelatinase reactivity (GEL: green; nuclei: red) in both leukocytes (K) and VSMCs (N) that were identified in serial sections (denoted by arrows) of actively remodeling arterioles, enlarged in L and O (CD45 and α-SMA serial stains not shown). M: Negative control for in situ zymography. Scale bars = 50 μm.