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. 2010 Aug;177(2):865–872. doi: 10.2353/ajpath.2010.091096

Figure 2.

Figure 2

Histopathological changes after low-dose (0.5 BED) UVB irradiation in skin humanized mice A–D: Histological sections of regenerated human skins taken immediately before 0.5 BED of UVB irradiation. A and C: Hematoxylin-eosin (H&E) staining. B and D: Immunoperoxidase staining of keratin K6. E–H: Histological sections of regenerated human skins taken 24 hours after 0.5 BED. E and G: H&E staining. F and H: Keratin K6 immunoperoxidase staining. Note the acanthosis (thickening) and K6-positive staining of Caucasian-derived skin (E and F, respectively). I–L: Histological sections of regenerated human skin taken 48 hours after 0.5 BED. I and K: H&E staining. J and L: Keratin K6 immunoperoxidase staining. Panels A, B, E, F, I, and J correspond to Caucasian-derived regenerated skin. Panels C, D, G, H, K, and L correspond to African descent-derived regenerated skins. Scale bar = 100 μm. M: Quantitative analysis of epidermal thickness at 24 and 48 hours after irradiation. Open bars indicate Caucasian-derived skins; shaded bars, African-derived skins. Scale bar = 100 μm. **P < 0.01.