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Endothelial-specific overexpression of Cav-1 enhances the progression of atherosclerosis. Oil Red O staining of aortas from mice with the indicated phenotypes. Atheroma formation was significantly increased in ApoE−/−Cav-1TG mice (n = 12) compared with ApoE−/− mice (n = 12). Similar results were observed in females [ApoE−/−Cav-1TG mice (n = 9); ApoE−/− mice (n = 6)].
