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Regulation of actin filament turnover. The Figure presents a simplified model of actin filament turnover and shows two mechanisms regulating the velocity of this process. The increased F-actin turnover can be mediated by actin-depolymerizing factor (ADF)/cofilin-driven F-actin depolymerization, whereas decreased turnover can be achieved by eplin and/or actinin-dependent filament cross-linking.
