Table 1.
Plasma and CSF Virus Load
| Group | Case number | Age (days) | NDI (days) | Plasma virus load (log10 copies/ml)
|
CSF virus load (log10 copies/ml)
|
Encephalitis | ||
|---|---|---|---|---|---|---|---|---|
| 21 dpi | Terminal | 21 dpi | Terminal | |||||
| Untreated | 1 | 3116 | 70 | 7.7 | 6.7 | 4.8 | 6.00 | +++ |
| 2 | 3487 | 57 | 7.7 | 7.6 | 5.2 | 5.5 | +++ | |
| 3 | 3489 | 63 | 7.1 | 7.7 | 4.5 | 4.3 | ++ | |
| 4 | 4606 | 85 | 6.6 | 7.6 | 5.7 | 5.0 | ++++ | |
| CART | 5 | 4025 | 57 | 7.4 | 5.4 | 5.7 | 3.9 | − |
| 6 | 7584 | 57 | 7.1 | 6.1 | 6.1 | 5.9 | − | |
| 7 | 3782 | 57 | 6.5 | 4.6 | * | 4.9 | − | |
| 8 | 3778 | 57 | 7.2 | 5.8 | * | 5.4 | − | |
*
Samples not available; Neuropathology scores for encephalitis severity: ++mild, +++moderate, ++++severe, −absent. NDI, number of days postinfection upon which animal was sacrificed.