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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Neurobiol Dis. 2010 May 20;39(3):409–422. doi: 10.1016/j.nbd.2010.05.013

Figure 3. Immunization with SDPM1 lowers brain levels of Aβ1–40 and Aβ1–42 in APPswePSEN1(A246E) transgenic mice.

Figure 3

(A–E) Aβ1–40 and Aβ1–42 levels were measured in Young (A–C) or Old (D–F) Mock-, SDPM1-, and SDPM2-immunized mice (with adjuvant) in cortex (A, D), hippocampus (B, E), or cerebellum (C, F). (G) Immunoblot with an Aβ1–42-specific polyclonal antiserum of 100µg of total SDS-soluble proteins isolated from Mock-immunized wild type (WT) or from Mock-, SDPM1- or SDPM2-immunized APPswePSEN1(A246E) cortex (APP/PS1). Examples from three different animals are shown per condition. Errors are SEM for n=7–12 animals per condition for n=3 measurements per animal per condition in A–F.