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. Author manuscript; available in PMC: 2010 Aug 2.
Published in final edited form as: J Neuroimmunol. 2008 Oct 15;203(1):23–32. doi: 10.1016/j.jneuroim.2008.06.034

Figure 1.

Figure 1

MHC class II+ cells were detected in the corpus callosum of cuprizone-treated mice.

(A) Illustration of the corpus callosum from which all coronally-sectioned mouse brains were analyzed near midline within the rectangular box. V = ventricle

(B) Brain sections were stained with anti-I-Ab antibody to identify MHC class II+ cells in the demyelinated corpus callosum at week 3.0 (200X magnification).

(C) MHC class II+ cells were quantified at weekly intervals during the 6 week exposure to cuprizone and were compared to untreated mouse brains (week 0). *Denotes p<0.05 by one-way analysis of variance (ANOVA) test followed by Dunnett multiple comparisons test comparing all time points to 0 week timepoint; n=3 mice each week