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. Author manuscript; available in PMC: 2010 Aug 2.
Published in final edited form as: J Neuroimmunol. 2008 Oct 15;203(1):23–32. doi: 10.1016/j.jneuroim.2008.06.034

Figure 3.

Figure 3

The absence of MHC class II or the cytoplasmic tail of MHC class II showed a reduced microglia/macrophage accumulation in the corpus callosum.

(A) Representative RCA-1-stained microglia/macrophages (brown-stained cells with nuclei and indicated by arrows) in the corpus callosum of untreated controls wild type, I-Aβ−/−, and I-Aβtr mice treated for 3 weeks with 0.2% cuprizone at 400X magnification are shown.

(B) Morphometric quantitation of RCA-1+ microglia/macrophages were facilitated by using the NIH Imaging software (Hiremath et al., 1998). The corpus callosum of wild type mice treated with cuprizone (n = 12 per genotype) for three weeks had greater numbers of microglia/macrophages than I-Aβ−/− or I-Aβtr mice. Statistical analyses were conducted by ANOVA using the Dunnett multiple comparison test comparing to wild type mice.