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TNF-α and IL-1β production in the brains of wild type mice was greater than I-Aβ−/− and I-Aβtr mice (n = 9-12 mice per genotype).
Brains of cuprizone-treated mice were homogenized in the presence of protease inhibitors and extracts were assayed for TNF-α and IL-1β using EIA. Statistical analyses were conducted by ANOVA using the Dunnett multiple comparison test comparing to wild type mice.
