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Nitrotyrosine staining was increased in cuprizone-treated wild type mice. The lack of nitrotyrosine staining indicated the absence of nitric oxide in the corpus callosum of untreated control mice, but its presence in 3 week, cuprizone-treated wild type mice. The level of nitrotyrosine staining was reduced in cuprizone-treated I-Aβ−/− and I-Aβtr mice (n = 4-5 mice per genotype).
