Table 3.
Chemotherapy and Acute Radiation Therapy Toxicities
| Group 1 (PTV2< 75 cc) |
Group 2 (PTV2 ≥ 75 cc) |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 66 Gy (n=22) Grade |
72 Gy (n=23) Grade |
78 Gy (n=27) Grade |
84 Gy (n=22) Grade |
66 Gy (n=33) Grade |
72 Gy (n=23) Grade |
78 Gy (n=35) Grade |
84 Gy (n=18) Grade |
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| Category | 3 | 4 | 5 | 3 | 4 | 3 | 4 | 3 | 4 | 3 | 4 | 3 | 4 | 3 | 4 | 5 | 3 | 4 | 5 |
| Blood/bone marrow | 3 | 7 | 0 | 8 | 6 | 9 | 5 | 4 | 5 | 13 | 2 | 5 | 5 | 11 | 3 | 0 | 5 | 2 | 0 |
| Cardiovascular (arrhythmia) |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Cardiovascular (general) |
0 | 1 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 1 | 2 | 0 | 2 | 1 | 1 | 2 | 0 | 0 |
| Coagulation | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Constitutional symptoms |
0 | 0 | 0 | 1 | 0 | 2 | 0 | 3 | 0 | 4 | 0 | 1 | 2 | 2 | 0 | 0 | 1 | 0 | 0 |
| Dermatology/skin | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| Gastrointestinal | 0 | 0 | 0 | 1 | 0 | 3 | 0 | 1 | 0 | 2 | 1 | 1 | 0 | 2 | 0 | 0 | 1 | 0 | 0 |
| Hemorrhage | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Hepatic | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Infection/febrile neutropenia |
1 | 0 | 0 | 2 | 0 | 3 | 1 | 2 | 0 | 5 | 0 | 3 | 0 | 4 | 0 | 0 | 1 | 1 | 0 |
| Metabolic/laboratory | 1 | 0 | 0 | 2 | 0 | 2 | 0 | 1 | 1 | 2 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Musculoskeletal | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 |
| Neurology | 3 | 0 | 0 | 1 | 0 | 5 | 0 | 2 | 0 | 3 | 1 | 3 | 0 | 2 | 1 | 0 | 3 | 0 | 0 |
| Ocular/visual | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Pain | 2 | 0 | 0 | 1 | 0 | 3 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 1 | 1 | 0 |
| Pulmonary | 1 | 0 | 1 | 2 | 0 | 1 | 2 | 0 | 0 | 2 | 1 | 0 | 1 | 0 | 2 | 0 | 0 | 1 | 1 |
| Renal/genitourinary | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Worst non- hematologic |
6 27% |
1 5% |
1 5% |
10 43% |
0 0% |
10 37% |
3 11% |
9 41% |
1 5% |
9 27% |
4 12% |
6 26% |
2 9% |
5 14% |
5 14% |
1 3% |
4 22% |
2 11% |
1 6% |
| Worst overall | 5 23% |
7 32% |
1 5% |
13 57% |
6 26% |
11 41% |
8 30% |
10 45% |
5 23% |
15 45% |
6 18% |
8 35% |
6 26% |
12 34% |
6 17% |
1 3% |
7 39% |
3 17% |
1 6% |