Table 3.
Association between smoking initiation, cessation and heavy smoking with rs16969968 genotype
|
Ever vs never smokers |
Current vs former smokers |
Heavy vs light current smokers |
Heavy vs light former smokers |
|||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ever | Never | OR | 95% CI | P-value | Current | Former | OR | 95% CI | P-value | Heavy | Light | OR | 95% CI | P-value | Heavy | Light | OR | 95% CI | P-value | |
| Controls | ||||||||||||||||||||
| GG | 2666 | 1432 | 1.00 | Ref. | – | 1253 | 1356 | 1.00 | Ref. | – | 273 | 332 | 1.00 | Ref. | – | 301 | 477 | 1.00 | Ref. | – |
| GA | 2720 | 1454 | 1.02 | 0.93–1.12 | 0.71 | 1295 | 1378 | 1.01 | 0.90–1.13 | 0.89 | 264 | 319 | 0.98 | 0.76–1.27 | 0.87 | 320 | 439 | 1.20 | (0.95–1.50) | 0.12 |
| AA | 710 | 387 | 1.00 | 0.87–1.16 | 0.95 | 336 | 360 | 0.99 | 0.83–1.19 | 0.93 | 78 | 53 | 1.60 | 1.04–2.46 | 0.03 | 80 | 112 | 1.21 | (0.85–1.73) | 0.28 |
| OR trend | – | – | 1.01 | 0.94–1.08 | 0.83 | – | – | 1.00 | 0.92–1.09 | 1.00 | – | – | 1.15 | 0.96–1.39 | 0.14 | – | – | 1.13 | (0.97–1.33) | 0.13 |
| LC cases | ||||||||||||||||||||
| GG | 1247 | 133 | 1.00 | Ref. | – | 890 | 342 | 1.00 | Ref. | – | 253 | 115 | 1.00 | Ref. | – | 97 | 75 | 1.00 | Ref. | – |
| GA | 1649 | 155 | 1.18 | 0.90–1.56 | 0.23 | 1179 | 452 | 0.94 | 0.79–1.12 | 0.48 | 366 | 145 | 1.10 | 0.78–1.53 | 0.59 | 122 | 90 | 1.30 | (0.81–2.09) | 0.27 |
| AA | 597 | 54 | 1.27 | 0.88–1.84 | 0.20 | 440 | 154 | 0.98 | 0.77–1.24 | 0.88 | 140 | 48 | 1.27 | 0.81–1.99 | 0.30 | 50 | 26 | 2.07 | (1.08–3.96) | 0.03 |
| OR trend | – | – | 1.14 | 0.95–1.36 | 0.15 | – | – | 0.98 | 0.88–1.10 | 0.74 | – | – | 1.12 | 0.90–1.39 | 0.30 | – | – | 1.41 | (1.03–1.92) | 0.03 |
| UADT cancer cases | ||||||||||||||||||||
| GG | 1569 | 132 | 1.00 | Ref. | – | 1187 | 380 | 1.00 | Ref. | – | 393 | 189 | 1.00 | Ref. | – | 126 | 72 | 1.00 | Ref. | – |
| GA | 1649 | 141 | 1.13 | 0.87–1.47 | 0.35 | 1261 | 388 | 1.13 | 0.94–1.35 | 0.18 | 460 | 153 | 1.37 | 1.03–1.82 | 0.03 | 128 | 68 | 1.11 | (0.68–1.79) | 0.68 |
| AA | 435 | 42 | 1.14 | 0.77–1.68 | 0.52 | 320 | 115 | 0.99 | 0.76–1.29 | 0.93 | 136 | 22 | 3.09 | 1.81–5.29 | <0.0001 | 31 | 23 | 0.77 | (0.37–1.60) | 0.49 |
| OR trend | – | – | 1.09 | 0.90–1.30 | 0.38 | – | – | 1.03 | 0.91–1.17 | 0.61 | – | – | 1.57 | 1.27–1.95 | <0.0001 | – | – | 0.94 | (0.67–1.32) | 0.73 |
| Cases and controls combined | ||||||||||||||||||||
| GG | 5482 | 1697 | 1.00 | Ref. | – | 3330 | 2078 | 1.00 | Ref. | – | 919 | 636 | 1.00 | Ref. | – | 524 | 624 | 1.00 | Ref. | – |
| GA | 6018 | 1750 | 1.04 | 0.96–1.13 | 0.34 | 3735 | 2218 | 1.01 | 0.93–1.10 | 0.79 | 1090 | 617 | 1.13 | 0.96–1.34 | 0.13 | 570 | 597 | 1.17 | (0.98–1.41) | 0.09 |
| AA | 1742 | 483 | 1.04 | 0.92–1.19 | 0.51 | 1096 | 629 | 0.98 | 0.87–1.11 | 0.77 | 354 | 123 | 1.81 | 1.39–2.35 | <0.0001 | 161 | 161 | 1.25 | (0.95–1.65) | 0.12 |
| OR trend | – | – | 1.03 | 0.97–1.09 | 0.36 | – | – | 1.00 | 0.94–1.06 | 0.91 | – | – | 1.27 | 1.13–1.43 | <0.0001 | – | – | 1.13 | (1.00–1.29) | 0.05 |
ORs are obtained by logistic regression, comparing GA and AA phenotype with GG phenotype. Adjusted for age, sex, country and case/control status for the combined analysis.
Ref. = reference.