. 2009 Sep 23;39(2):563–577. doi: 10.1093/ije/dyp288

Table 5.

Association between age of onset of LC and UADT cancer with rs16969968 genotype

LC						UADT cancer
		n	Adj. mean	95% CI	P-trend			n	Adj. mean	95% CI	P-trend
Overall	GG	1405	61.8	61.2–62.3		Overall	GG	1701	58.5	57.8–59.2
	GA	1828	61.5	61–62			GA	1790	58.2	57.5–58.9
	AA	665	60.7	59.9–61.4	0.02		AA	477	57.6	56.6–58.6	0.10
	Diff. in years^a		1.1				Diff. in years^a		0.9
Central Europe	GG	640	59.4	58.6–60.2		Central Europe	GG	305	57.6	56.1–59.2
	GA	854	59.3	58.6–60			GA	331	56.9	55.5–58.4
	AA	296	59.2	58.1–60.3	0.80		AA	83	56.9	54.7–59.2	0.38
	Diff. in years^a		0.2				Diff. in years^a		0.7
Toronto	GG	122	62	59.8–64.2		ARCAGE	GG	576	58.4	57.3–59.5
	GA	154	63.1	61.1–65.1			GA	757	58.4	57.4–59.5
	AA	53	62.8	59.5–66.4	0.56		AA	220	56.8	55.3–58.4	0.14
	Diff. in years^a		–0.8				Diff. in years^a		1.6
EPIC	GG	399	62.6	61.7–63.4		Latin America	GG	743	59.4	58.2–60.6
	GA	555	62.5	61.8–63.2			GA	561	59.3	58.1–60.6
	AA	222	61	60–62	0.02		AA	125	59.6	57.5–61.7	0.96
	Diff. in years^a		1.6				Diff. in years^a		–0.2
Liverpool	GG	168	67.7	66.3–69.1		Rome	GG	77	64.9	61.9–68
	GA	165	65.6	64.2–67			GA	141	61.8	59.4–64.2
	AA	56	64.5	62.2–66.8	0.008		AA	49	62.4	58.9–66.2	0.20
	Diff. in years^a		3.2				Diff. in years^a		2.5
Hunt/Tromso	GG	76	64	61.4–66.6		P-heterogeneity between studies					0.58
	GA	100	62.2	60.1–64.4
	AA	38	57.7	54.5–61	0.006
	Diff. in years^a		6.3
P-heterogeneity between studies					0.02

Linear regression of age of onset was performed. Means are adjusted for sex and country.

Difference in years between homozygous variant (AA) and homozygous (GG) genotypes.