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. Author manuscript; available in PMC: 2010 Aug 2.
Published in final edited form as: J Immunol. 2008 Mar 15;180(6):3833–3838. doi: 10.4049/jimmunol.180.6.3833

Figure 2. The kinase domain of Itk is required for the production of Th2 cytokines in the lung during the development of allergic asthma.

Figure 2

(a) WT, Itk−/−, Tg(Lckpr-ItkΔKin)/Itk−/−, and Tg(Lckpr-ItkΔKin)/WT mice were treated as in figure 1, lungs isolated and mRNA for the IL-4, -13 and IFNγ quantified by Q-RT-PCR. (b) BAL fluid from WT, Itk−/−, Tg(Lckpr-ItkΔKin)/Itk−/−, and Tg(Lckpr-ItkΔKin)/WT mice treated as in figure 1 were isolated and the amounts of IL-4, -5 and -13 quantified. *p<0.05 vs. WT mice, ND, none detected.