Figure 7.

The voltage prepulse has minimal effects on somatic Na⁺ currents. A, B, Example showing a comparison between Na⁺ currents recorded from a dissociated cortical pyramidal neuron, without (A) or with (B) the voltage prepulse. There is limited activation and inactivation of Na_v channels during the prepulse causing only a small reduction in the current evoked by the subsequent voltage steps (B). The inset in B contains the I-V curve obtained without (black plots) or with (red plots) prepulse. The traces were recorded with internal solutions containing 13 mm Na⁺ and were TTX subtracted. C, Voltage-clamp protocol.