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. Author manuscript; available in PMC: 2010 Aug 2.
Published in final edited form as: Mol Cell Pharmacol. 2010;2(3):101–110.

Figure 1. Schematic depiction of the roles of the PMCT and the CTP in supplying citrate to fuel hepatic fatty acid, triacylglycerol, and sterol biosyntheses.

Figure 1

Citrate can be transported from the blood across the hepatocyte plasma membrane into the cytoplasm on the PMCT, or it can be effluxed from the mitochondrial matrix across the mitochondrial inner membrane on the CTP. Cytoplasmic citrate derived from either source is then broken down to acetyl CoA by citrate lyase, and the resulting acetyl CoA provides all of the carbon precursor to fuel the fatty acid, triacylglycerol, and sterol biosynthetic pathways.