Table 2.
Results of SCT for Pediatric Patients with ALL in Second Remission
| Study Group | Dates of Study |
Patients (n) | Outcome (years) |
Reference |
|---|---|---|---|---|
| BFM | 1985–91 | 51 MRD | 52% EFS (5) | Dopfer 1991 [160] |
| IBMTR/POG | 1983–91 | 255 MRD | 40% DFS (5) | Barrett 1994 [51] |
| 255 chemo | 17% DFS (5) | |||
| Leiden | 1982–91 | 25 MRD | 44% DFS (4) | Hoogerbrugge 1995 [161] |
| 97 chemo | 24% DFS (4) | |||
| AIEOP/GITMO | 1980–90 | 57 MRD | 41% DFS (5) | Uderzo 1995 [162] |
| 230 chemo | 21% DFS (5) | |||
| Paris | 1983–93 | 42 MRD | 53% (4) | Moussalem 1995 [163] |
| UKALL-X | 1985–90 | 83 MRD, 27 MUD | 40% EFS(5) | Wheeler 1998 [164] |
| 61 ABMT | 34% EFS | |||
| 261 chemo | (5) 26% EFS (5) | |||
| UKALL-R1 | 1991–95 | 63 MRD | 46% EFS (5) | Harrison 2000 [165] |
| 41 MUD | 54% EFS (5) | |||
| 15 ABMT, 89 chemo | 43% EFS (5) | |||
| IBMTR/COG | 1991–97 | CR1 < 36 months | Eapen 2006 [52] | |
| 92 MRD + TBI | 32% OS (8) | |||
| 19 MRD no TBI | 44% OS (8) | |||
| 110 Chemo | (8)18% OS | |||
| CR1 ≥ 36 months | ||||
| 61 MRD + TBI | 66% OS (8) | |||
| 14 MRD no TBI | 63% OS (8) | |||
| 78 Chemo | 32% OS (8) | |||
| COG | 1995–98 | 32 MRD | 42% DFS (3) | Gaynon 2006 [45] |
| 19 MUD | 29% DFS (3) | |||
| 23 chemo | 30% DFS (3) | |||
chemo = chemotherapy, MUD = matched unrelated donor, MRD = matched related donor, EFS = event free survival, DFS = disease free survival, OS = overall survival, ABMT = autologous bone marrow transplant, TBI = total body irradiation